Investigators: Mr Alister Hart, Dr Barry Sampson, Dr Ann Sandison, Professor J Powel, Dr J Mosselmans, Mr J Skinner, Dr K Atkinson, Professor Julia Shelton, Dr A Angadji
Stream: Clinical Fellowship
Topic: Lower Limbs / Biology (Hip)
Status: Completed
This grant was successful because of the multiple firsts it achieved in a highly controversial area. It is an example of translational, “bench to bedside” research that will hopefully go on to benefit patients.First, we developed new methodologies for the metal mapping of tissue surrounding metal-on-metal hips using laser ablation mass spectrometry. Secondly, we were the first to apply new methods to allow Synchrotron radiation to map metal and determine metal speciation in tissue taken from current generation metal on metal hip replacements.
These original experiments enabled us to make three new observations, first, the relatively few nanoparticles in the tissue when compared to the abundance of Chromium (III), secondly the absence of Cr(VI), and lastly, the likelihood that wear rather than corrosion was responsible for the chromium phosphate in the tissues.
The above have been communicated, acknowledging the Furlong Research Charitable Foundation, in the form of 1 published conference abstract, 1 paper submitted and 1 AAOS conference paper in preparation submitted. One further paper is being prepared.
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