Institution: The Royal National Orthopaedic Hospital (RNOH), Stanmore
Investigators: Professor Tim Briggs, Mr Ben Spiegelberg
Stream: Clinical Fellowship
Topic: General Orthopaedic (Implant Infection)
Status: Live
Small metallic heads have traditionally been used to articulate with an UHMWPE cups in total hip arthroplasty (THR). More recently, however, there has been an increasing trend towards performing THR in younger patients. These patients are more active and thus, in order to attempt to give them a greater range of motion and reduced dislocation rates, larger head sizes are being used.
Metal-on-Metal (MoM) bearings have been widely reported to be associated with raised levels of metal ions (Co, Cr) and more recently abnormalities in T-cell sensitivities. In addition, research from our centre has shown that MoM bearings have been associated with chromosomal aberrations. It is thought that metal-on-polyethylene (MoPE) bearings in hip replacements will be associated with lower levels of metal ions in the blood, less T-cell abnormalities and less chromosomal aberrations. It is not known whether the presence of these abnormalities will have any clinical consequences.
The aims of this study are to confirm the presence of raised whole blood metal ion levels, abnormal T-cell sensitivities and chromosomal aberrations in patients with MoM implants, as well as to determine whether patients with MoPE will be associated with lower levels of ions in the blood, less T-cell abnormalities and less chromosomal aberrations.
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Whole Blood Metal Ion Levels
Immune Responses and Chromosomal Analysis in Patients with Metal-on-Metal and Metal-on-Pol
